In immediate opening is available for a Research Associate (Post-Doctoral) in the Neubig Lab (Pharmacology & Toxicology, Michigan State University, East Lansing MI).
Seeking a candidate with strong experience in biochemistry, molecular pharmacology, and/or gene transcription mechanisms. Specific expertise in recombinant protein expression (especially mammalian or insect cells) as well as protein purification, biophysical analysis of protein structure/function, and small molecule binding analysis are desirable.
The ideal candidate will provide strong evidence of research productivity and drive. Recent PhD graduates preferred. The project relates to recently identified small molecule inhibitors of the Rho/MRTF/SRF gene transcription pathway (PMID: 23707258). They have been shown to have preclinical activity in fibrotic disease models and cancer metastasis (PMID: 24706986, 27837031). Based on the discovery of Pirin as a novel molecular target for these compounds (https://tinyurl.com/pirinpaper) and a role for pirin in the actions of multiple transcription factors including NF-kB, the candidate will undertake purification of pirin and characterize its interactions with and modulation of gene transcription. Interactions with and modulation by our small molecule inhibitors will also be explored.
Doctorate -Cancer Pharmacology or Cancer Biology
Recent Ph.D. graduate
Highly motivated scientist with experience in cancer pharmacology or cancer biology, and gene transcription analysis
Provide strong evidence of research productivity and drive
Required Application Materials
3 references (names and contact information)
Summary of Health Risks
Exposure to human blood, serum, tissue, and other body fluids; and materials covered under universal Michigan State University Environmental Health and Safety and MSU Occupational Health. Work with animals or unfixed animal tissue.
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Internal Number: 595630
About Michigan State University
Spartans work every day to advance the common good in uncommon ways.Together, we tackle some of the world?s toughest problems to find solutions that make life better?from alternative energy to better food safety to breakthrough medical and environmental applications achieved through rare isotope research.We teach. We explore and we discover. We collaborate and lead. We innovate, inspire, and empower. We achieve our potential and create circumstances that help our students and others achieve theirs.We're good at it, and we've been at it for more than 150 years.The nation?s pioneer land-grant university, MSU began as a bold experiment that democratized higher education and helped bring science and innovation into everyday life. The revolutionary concept became a model for the nation.Today, MSU is one of the top research universities in the world?on one of the biggest, greenest campuses in the nation. Home to nationally ranked and recognized academic, residential college, and service-learning programs, we?re a diverse community of dedicated students and scholars, athletes and artists, scientists and leaders.In ways both practical and profound, we work to create a stronger, more sustainable, and more hopeful future for all.