The Bin Chen Laboratory (http://binchenlab.org) uses big data and artificial intelligence to discover new or better therapeutic candidates. The lab has collected over 30,000 bulk RNA-Seq profiles and millions of single-cell RNA-Seq profiles and drug-induced gene expression profiles. The lab is now capable of screening drug candidates from millions of novel compounds for a given disease gene expression signature. Our postdoctoral Research Associate will help refine the models and translate these data into therapeutics.
The successful candidate is expected to lead or assist with any of the following projects:
Developing deep learning and transfer learning algorithms to discover novel therapeutics and transfer knowledge between preclinical and clinical models
Improving and implementing a systems-approach (http://octad.org) to discover therapeutics for various diseases (including liver cancer, DIPG, melanoma, MODS, metastatic breast cancer or any other conditions you are passionate about)
The Chen Lab is located along the Medical Mile in beautiful downtown Grand Rapids. Our Secchia Center facilities are modern and comfortable. We are a welcoming team with members from all over the world. Our work depends on close collaborations with outstanding bench scientists, data scientists, and clinicians; the successful candidate will have the opportunity to form strong working relationships at Michigan State University, Van Andel Research Institute, Spectrum Health, the University of California Berkeley, the University of California San Francisco, and Stanford University. Recent Chen Lab work has been published in Gastroenterology, Nature Communications, Nature Protocols, and Nature Reviews Gastroenterology and Hepatology, and featured in STAT, GEN, GenomeWeb, and KCBS.
Equal Employment Opportunity Statement
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, age, disability or protected veteran status.
Doctorate -Bioinformatics, Chemical Informatics, Bi
Ph.D. or M.D./Ph.D. in Bioinformatics, Chemical Informatics, Biostatistics, Statistics, Computational Biology, Informatics, Computer Science, or a related field.
Experience with machine learning/statistical learning
Prior evidence of productivity, creativity, and passion for drug discovery
Excellent communication skills in English
Proficiency in using R/Bioconductor and Python
Strong background in cancer genomics and computational drug discovery
Required Application Materials
CV and cover letter
Please attach cover letter and CV to your application.
Review of applications will begin immediately and continue until the position is filled.
Review of Applications Begins On
Established in 1968 with the formation of the Michigan State University College of Human Medicine, the Department of Pediatrics and Human Development seeks to balance behavioral science, basic biological research, and clinical pediatrics into a comprehensive approach to the health and development of the child and the family.
Michigan State University has been advancing the common good with uncommon will for more than 160 years. One of the top research universities in the world, MSU pushes the boundaries of discovery and forges enduring partnerships to solve the most pressing global challenges while providing life-changing opportunities to a diverse and inclusive academic community through more than 200 programs of study in 17 degree-granting colleges.
Spartans work every day to advance the common good in uncommon ways.Together, we tackle some of the world?s toughest problems to find solutions that make life better?from alternative energy to better food safety to breakthrough medical and environmental applications achieved through rare isotope research.We teach. We explore and we discover. We collaborate and lead. We innovate, inspire, and empower. We achieve our potential and create circumstances that help our students and others achieve theirs.We're good at it, and we've been at it for more than 150 years.The nation?s pioneer land-grant university, MSU began as a bold experiment that democratized higher education and helped bring science and innovation into everyday life. The revolutionary concept became a model for the nation.Today, MSU is one of the top research universities in the world?on one of the biggest, greenest campuses in the nation. Home to nationally ranked and recognized academic, residential college, and service-learning programs, we?re a diverse community of dedicated students and scholars, athletes and artists, scientists and leaders.In ways both practical and profound, we work to create a stronger, more sustainable, and more hopeful future for all.